Sticky stuff: xerostomia in patients undergoing head and neck radiotherapy-prevalence, prevention, and palliative care. 2020

James William Snider, and Charles Christian Paine
Department of Radiation Oncology, University of Alabama at Birmingham, UAB Proton Center, Birmingham, AL, USA. jwsnider@uabmc.edu.

Xerostomia remains one of the most common and impactful side effects associated with radiotherapy for head and neck malignancies. With improvements in oncologic therapy and an improved prognosis for patients with head and neck squamous cell carcinoma (HNSCC) overall, the long-standing effects of therapy have become even more significant. Recent efforts have primarily focused on prevention of this morbidity through technological advances, reductions in radiotherapy fields, and radioprotectants. The promises of de-intensified strategies and proton radiation warrant ongoing investigation. However, palliative care for and active management of xerostomia before, during, and after treatment deserve further attention and research to define optimal approaches.

UI MeSH Term Description Entries
D010166 Palliative Care Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed) Palliative Treatment,Palliative Supportive Care,Palliative Surgery,Palliative Therapy,Surgery, Palliative,Therapy, Palliative,Care, Palliative,Palliative Treatments,Supportive Care, Palliative,Treatment, Palliative,Treatments, Palliative
D006258 Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) Cancer of Head and Neck,Head Cancer,Head Neoplasm,Head and Neck Cancer,Head and Neck Neoplasm,Neck Cancer,Neck Neoplasm,Neck Neoplasms,Neoplasms, Upper Aerodigestive Tract,UADT Neoplasm,Upper Aerodigestive Tract Neoplasm,Upper Aerodigestive Tract Neoplasms,Cancer of Head,Cancer of Neck,Cancer of the Head,Cancer of the Head and Neck,Cancer of the Neck,Head Neoplasms,Head, Neck Neoplasms,Neoplasms, Head,Neoplasms, Head and Neck,Neoplasms, Neck,UADT Neoplasms,Cancer, Head,Cancer, Neck,Cancers, Head,Cancers, Neck,Head Cancers,Neck Cancers,Neoplasm, Head,Neoplasm, Neck,Neoplasm, UADT,Neoplasms, UADT
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014987 Xerostomia Decreased salivary flow. Asialia,Hyposalivation,Mouth Dryness,Asialias,Dryness, Mouth,Hyposalivations,Xerostomias
D015995 Prevalence The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time. Period Prevalence,Point Prevalence,Period Prevalences,Point Prevalences,Prevalence, Period,Prevalence, Point,Prevalences
D018787 Radiation Oncology A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer. Oncology, Radiation,Radiology, Therapeutic,Therapeutic Radiology

Related Publications

James William Snider, and Charles Christian Paine
May 2006, Current opinion in oncology,
James William Snider, and Charles Christian Paine
December 2022, Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India,
James William Snider, and Charles Christian Paine
June 2022, BMC cancer,
James William Snider, and Charles Christian Paine
January 1995, Revue belge de medecine dentaire,
James William Snider, and Charles Christian Paine
April 2013, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer,
James William Snider, and Charles Christian Paine
January 1992, Ugeskrift for laeger,
James William Snider, and Charles Christian Paine
February 2003, Archives of otolaryngology--head & neck surgery,
James William Snider, and Charles Christian Paine
September 2021, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery,
James William Snider, and Charles Christian Paine
January 2003, Cancer detection and prevention,
James William Snider, and Charles Christian Paine
March 2011, Nature reviews. Clinical oncology,
Copied contents to your clipboard!