Biomaterial Database

Comparison of 0.5% cyclopentolate plus 0.5% tropicamide and 1% cyclopentolate alone for mydriasis of dark irides. 1988

A R Nishizawa, and R B Orton, and W Cadera

Ivey Institute of Ophthalmology, Victoria Hospital, London, Ont.

We studied the mydriatic and cycloplegic effect of a single dose of a combination of 0.5% cyclopentolate hydrochloride and 0.5% tropicamide in 20 healthy subjects with dark brown irides. The mean change in dilatation with the combination drop was 3.5 mm, compared with 0.6 mm with 1% cyclopentolate alone (p less than 0.001). In 92% of 26 eyes studied the difference in refraction between the combination drop and 1% atropine was +1.00 dioptre or less. The combination drop safely provided satisfactory mydriasis and cycloplegia in 20 minutes, allowing for rapid and accurate examination of these patients.

UI	MeSH Term	Description	Entries
D010648	Phenylacetates	Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID.	Benzeneacetates,Benzeneacetic Acids,Phenylacetic Acids,Acids, Benzeneacetic,Acids, Phenylacetic
D011680	Pupil	The aperture in the iris through which light passes.	Pupils
D011725	Pyridines	Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D003519	Cyclopentolate	A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.	Cyclogyl
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D005127	Eye Color	Color of the iris.	Color, Eye,Colors, Eye,Eye Colors
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001285	Atropine	An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.	AtroPen,Atropin Augenöl,Atropine Sulfate,Atropine Sulfate Anhydrous,Atropinol,Anhydrous, Atropine Sulfate,Augenöl, Atropin,Sulfate Anhydrous, Atropine,Sulfate, Atropine
D014331	Tropicamide	One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.	Colircusi Tropicamida,Minims Tropicamide,Mydral,Mydriafair,Mydriaticum,Mydrum,N-Ethyl-N-(4-pyridylmethyl)tropamide,N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide,Ocu-Tropic,Tropicacyl,Tropicamide Faure,Tropicamide Minims,Tropicamide Monofree,Tropicamide Monohydrochloride, (R)-Isomer,Tropicamide Monohydrochloride, (S)-Isomer,Tropicamide, (+-)-Isomer,Tropicamide, (R)-Isomer,Tropicamide, (S)-Isomer,Ocu Tropic,OcuTropic