Biomaterial Database

Systems biology approach: Panacea for unravelling host-virus interactions and dynamics of vaccine induced immune response. 2016

Sajad Ahmad Wani, and Amit Ranjan Sahu, and Shikha Saxena, and Shahid Hussain, and Aruna Pandey, and Sonam Kanchan, and Aditya Prasad Sahoo, and Bina Mishra, and Ashok Kumar Tiwari, and Bishnu Prasad Mishra, and Ravi Kumar Gandham, and Raj Kumar Singh

Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar 243122, India.

Systems biology is an interdisciplinary research field in life sciences, which involves a comprehensive and quantitative analysis of the interactions between all of the components of biological systems over time. For the past 50 years the discipline of virology has overly focused on the pathogen itself. However, we now know that the host response is equally or more important in defining the eventual pathological outcome of infection. Systems biology has in recent years been increasingly recognised for its importance to infectious disease research. Host-virus interactions can be better understood by taking into account the dynamical molecular networks that constitute a biological system. To decipher the pathobiological mechanisms of any disease requires a deep knowledge of how multiple and concurrent signal-transduction pathways operate and are deregulated. Hence the intricacies of signalling pathways can be dissected only by system level approaches.