OBJECTIVE To develop a method for the determination of 11 perfluorinated compounds(PFCs) in drinking water by solid phase extraction-ultra performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS). METHODS The target analytes in water samples were concentrated and purified by Oasis WAX SPE column and eluted with 5 mL methanol and 7 mL 0. 1% ammonia-methanol solution. The eluent was blown to near dryness under a nitrogen gas, diluting with methanol water solution(3∶7, V/V) to 1 mL for analysis by UPLC-MS/MS. RESULTS There were good liner relationship in the range of 0. 5-50 μg/L. The detection limit and the limit of quantitation were 0. 03-0. 7 ng/L and 0. 5-3. 0 ng/L, respectively. The recoveries of 11 PFCs at three different spiked concentrations were 90. 0%-122. 3%, 87. 1%-130. 0% and 80. 0%-113. 7%, respectively, and the relative standard deviation were 1. 95%-8. 59%, 1. 27%-9. 08% and 2. 17%-10. 51%(n=6), respectively. CONCLUSIONS This method has wide linear range, low detection limit and limit of quantitation, applicable for simultaneous analysis and monitorting of 11 PFCs in drinking water.