Self-powered electronic skin is a promising field for human-machine interfaces to the next generation of intelligent and interactive products due to its capability of including multiple physical parameters for sensing without additional energy supply. This paper reports a novel active multifunctional electronic skin capable of independently detecting contact trajectory, acceleration, velocity, and pressure based on the synchronized triboelectrification and piezoelectric effect. Motion trajectories in the full plane can be identified by using a net-cross electrodes configuration design. Under this electrode special structure design, the motion information such as velocity and acceleration can be accurately obtained by the time difference between the peak values of the triboelectric signal. Real-time detection of dynamic pressure with only two electrodes is achieved by a spacer-grid design and a high quality piezoelectric nanofiber film. By virtue of its high sensitivity and precision, a smart anti-counterfeiting signature system (SASS) can be achieved by this self-powered multifunctional electronic skin with the capability of recognizing the writing habits of people within a 100 ms error for security. It is also a promising candidate in terms of human-machine interaction, cyber security, and so on.