-transparent.png){kind=logo}
The efficacy and toxicity of tolamolol and methyldopa in hypertensive patients has been compared by a dose-titrated, double-blind, cross-over study. Thirteen patients completed the trial. Within the dose ranges investigated (tolamolol - 300 mg/day - 900 mg/day; methyldopa - 750 mg/day - 2250 mg/day)both drugs produced significant falls in laying and standing, systolic and diastolic blood pressures. Although the hypotensive effects of methyldopa were more marked than tolamolol, these only achieved conventional (P less than 0.05) levels of significance for lying blood pressure. There were no objective changes in haematological or biochemical indices during treatment with either drug, but patients complained of tiredness, weak limbs and mouth dryness significantly more during methyldopa treatment, than during either placebo or tolamolol therapy.
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
January 1974,
Acta cardiologica,
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
May 1973,
Ugeskrift for laeger,
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
December 1976,
Annals of clinical research,
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
January 1983,
The British journal of clinical practice,
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
July 1975,
Current therapeutic research, clinical and experimental,
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
January 1986,
Journal of cardiovascular pharmacology,
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
March 1976,
Lancet (London, England),
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
October 1979,
The Medical journal of Australia,
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
February 1987,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
P A Routledge, and
L V Zrinzo, and
J G Rao, and
R J Walden, and
D M Davies, and
M D Rawlins
January 1986,
Acta obstetricia et gynecologica Scandinavica,
