BACKGROUND The SynCardia total artificial heart (TAH)® is the only approved TAH device. This report summarizes our single-center experience with the SynCardia TAH® with particular focus on the outcome after subsequent heart transplantation. METHODS We retrospectively analysed the outcome of all transplanted SynCardia TAH® patients at our center between 2001 and 2019 in comparison to transplanted left ventricular assist device (LVAD) and biventricular assist device (BVAD) patients and to transplanted patients without prior durable mechanical circulatory support (non-MCS). RESULTS Only a fraction (n=69; 37.3%) of all SynCardia TAH® patients (n=193) were transplanted. The majority (81.2%) of those were in high-urgency status at the time of transplantation. Survival in transplanted SynCardia TAH® patients was significantly poorer when compared to LVAD-, BVAD- and non-MCS patients (P=0.008). CONCLUSIONS Heart transplantation in SynCardia TAH® patients requires distinct risk stratification to improve outcomes.