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Normal rabbit alveolar macrophages were infected in vitro with Candida albicans. Early after infection, germ tube formation of phagocytized C. albicans was inhibited in contrast to extracellular (nonphagocytized) C. albicans. Over and 8-h period, plate counts of C. albicans incubated with alveolar macrophages revealed a decrease in colony-forming units in contrast to C. albicans alone. In addition, an assay was developed which specifically measured C. albicans [3H]leucine incorporation in the presence of alveolar macrophages. Using this assay, we observed a 71 to 93% inhibition of macromolecular synthesis in C. albicans when incubated with alveolar macrophages. Autoradiographic studies showed that the inhibition of leucine incorporation was restricted to the ingested Candida.
E M Peterson, and
R A Calderone
July 1977,
Sabouraudia,
E M Peterson, and
R A Calderone
June 1980,
Infection and immunity,
E M Peterson, and
R A Calderone
August 1994,
The American journal of physiology,
E M Peterson, and
R A Calderone
February 2010,
Applied microbiology and biotechnology,
E M Peterson, and
R A Calderone
February 1982,
Clinical immunology and immunopathology,
E M Peterson, and
R A Calderone
May 1995,
Journal of immunology (Baltimore, Md. : 1950),
E M Peterson, and
R A Calderone
February 1994,
Journal of leukocyte biology,
E M Peterson, and
R A Calderone
January 1999,
Microbiology and immunology,
E M Peterson, and
R A Calderone
June 1988,
Bratislavske lekarske listy,
E M Peterson, and
R A Calderone
April 2010,
American journal of respiratory cell and molecular biology,
