Biomaterial Database

Effect of substrate-free albumin on perfused rat kidney function. 1988

M Zamlauski-Tucker, and J J Cohen

Department of Physiology, University of Rochester School of Medicine and Dentistry, N.Y.

The effect of varying concentrations of substrate-free albumin (SFA) in the absence of exogenous substrate was investigated in the isolated perfused rat kidney. Consistent with starling relationship, there was a progressive decrease in glomerular filtration rate (GFR), from 778 +/- 36 to 41 +/- 17 microliters/min.g, and a progressive increase in fractional sodium reabsorption (%TNa+), from 31.1 +/- 0.9 to 82.6 +/- 2.3%, when the mean SFA concentration in the perfusate was increased from 3 to 10 g/dl. Perfusate flow rate (PFR) remained constant at 30 ml/min.g as the GFR decreased. When the mean perfusate SFA concentration was decreased from 3 g/dl to 0, the anticipated decrease in %TNa+ occurred but the increase in GFR did not. PFR was also reduced by one half when SFA was not present in the perfusion medium. The reason for the anomalous behavior of GFR and PFR when SFA was omitted from the perfusion medium is not clear.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D000042	Absorption	The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D000418	Albumins	Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.	Albumin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012964	Sodium	A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.	Sodium Ion Level,Sodium-23,Ion Level, Sodium,Level, Sodium Ion,Sodium 23
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus