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Oral Cannabidiol Does Not Convert to Δ8-THC or Δ9-THC in Humans: A Pharmacokinetic Study in Healthy Subjects. 2020
José Alexandre S Crippa, and
Antonio Waldo Zuardi, and
Jaime Eduardo Cecílio Hallak, and
Bruna Miyazawa, and
Sandra Aparecido Bernardo, and
Carmem Maria Donaduzzi, and
Silvane Guzzi, and
Wagner Alex Jann Favreto, and
Alline Campos, and
Maria Eugênia C Queiroz, and
Francisco S Guimarães, and
Patrícia Moura da Rosa Zimmermann, and
Letícia Mello Rechia, and
Volnei Jose Tondo Filho, and
Liberato Brum Junior
Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Introduction: Recent studies have suggested that cannabidiol (CBD) could interconvert into Delta-8- and Delta-9- tetrahydrocannabinol. Materials and Methods: Thus, we tested the plasma samples of 120 healthy human subjects (60 male and 60 female), 60 in fasting and the other 60 under normal feeding conditions after acute administration of an oral solution containing CBD 300 mg. To do this, we developed a bioanalytical method to determine CBD and the presence of THC in plasma samples by Ultra-High Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. Results: The results showed that THC was not detected in plasma after the administration of CBD, and those study participants did not present psychotomimetic effects. Conclusions: The findings presented here are consistent with previous evidence suggesting that the oral administration of CBD in a corn oil formulation is a safe route for the administration of the active substance without bioconversion to THC in humans.
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