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Development of new self-assembled cationic amino liposomes for efficient gene delivery. 2020
Yihang Wu, and
Yue Xiong, and
Ling Wang, and
Quanming Zhou, and
Linxian Li, and
Pavel A Levkin, and
Gary Davidson, and
Liqian Gao, and
Wenbin Deng
School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, P.R. China. gaolq@mail.sysu.edu.cn glqustc@gmail.com dengwb5@mail.sysu.edu.cn.
A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity.
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