-transparent.png){kind=logo}
Immunophenotyping of A20 haploinsufficiency by multicolor flow cytometry. 2020
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan; Department of Pediatrics, National Hospital Organization, Nagara Medical Center, Gifu, Japan.
Haploinsufficiency of A20 (HA20) causes inflammatory disease resembling Behçet's disease; many cases have been reported, including some that are complicated with autoimmune diseases. This study aims to clarify the immunophenotype of patients with HA20 by analyzing lymphocyte subsets using multicolor flow cytometry. The patients with HA20 previously diagnosed in a nationwide survey were compared by their cell subpopulations. In total, 27 parameters including regulatory T cells (Tregs), double-negative T cells (DNTs), and follicular helper T cells (TFHs) were analyzed and compared with the reference values in four age groups: 0-1, 2-6, 7-19, and ≥20 years. The Tregs of patients with HA20 tended to increase in tandem with age-matched controls at all ages. In addition, patients ≥20 years had increased DNTs compared with controls, whereas TFHs significantly increased in younger patients. In HA20 patients, the increase in DNTs and TFHs may contribute to the development of autoimmune diseases.
Related Publications
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
January 2019,
Methods in molecular biology (Clifton, N.J.),
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
September 2000,
Journal of immunological methods,
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
January 2017,
Methods in molecular biology (Clifton, N.J.),
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
January 2004,
Methods in cell biology,
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
January 2019,
Methods in molecular biology (Clifton, N.J.),
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
January 1993,
Diagnostic cytopathology,
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
April 2006,
Journal of immunological methods,
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
April 2017,
Current protocols in immunology,
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
August 2016,
International journal of molecular sciences,
Tomonori Kadowaki, and
Hidenori Ohnishi, and
Norio Kawamoto, and
Saori Kadowaki, and
Tomohiro Hori, and
Kenichi Nishimura, and
Chie Kobayashi, and
Tomonari Shigemura, and
Shohei Ogata, and
Yuzaburo Inoue, and
Eitaro Hiejima, and
Kazushi Izawa, and
Tadashi Matsubayashi, and
Kazuaki Matsumoto, and
Kohsuke Imai, and
Ryuta Nishikomori, and
Shuichi Ito, and
Hirokazu Kanegane, and
Toshiyuki Fukao
April 2013,
Annals of hematology,
