Redox toxicology of environmental chemicals causing oxidative stress. 2020

Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, 350122, China; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY, 10461, United States. Electronic address: f.zheng@fjmu.edu.cn.

Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regulations are also reviewed.

UI MeSH Term Description Entries
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D010575 Pesticides Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc. Pesticide
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000975 Antioxidants Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. Anti-Oxidant,Antioxidant,Antioxidant Activity,Endogenous Antioxidant,Endogenous Antioxidants,Anti-Oxidant Effect,Anti-Oxidant Effects,Anti-Oxidants,Antioxidant Effect,Antioxidant Effects,Activity, Antioxidant,Anti Oxidant,Anti Oxidant Effect,Anti Oxidant Effects,Anti Oxidants,Antioxidant, Endogenous,Antioxidants, Endogenous
D051267 NF-E2-Related Factor 2 A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage. Nfe2l2 Protein,Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein,Nuclear Factor E2-Related Factor 2,NF E2 Related Factor 2,Nuclear Factor E2 Related Factor 2
D018384 Oxidative Stress A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi). Anti-oxidative Stress,Antioxidative Stress,DNA Oxidative Damage,Nitro-Oxidative Stress,Oxidative Cleavage,Oxidative DNA Damage,Oxidative Damage,Oxidative Injury,Oxidative Nitrative Stress,Oxidative Stress Injury,Oxidative and Nitrosative Stress,Stress, Oxidative,Anti oxidative Stress,Anti-oxidative Stresses,Antioxidative Stresses,Cleavage, Oxidative,DNA Damage, Oxidative,DNA Oxidative Damages,Damage, DNA Oxidative,Damage, Oxidative,Damage, Oxidative DNA,Injury, Oxidative,Injury, Oxidative Stress,Nitrative Stress, Oxidative,Nitro Oxidative Stress,Nitro-Oxidative Stresses,Oxidative Cleavages,Oxidative DNA Damages,Oxidative Damage, DNA,Oxidative Damages,Oxidative Injuries,Oxidative Nitrative Stresses,Oxidative Stress Injuries,Oxidative Stresses,Stress Injury, Oxidative,Stress, Anti-oxidative,Stress, Antioxidative,Stress, Nitro-Oxidative,Stress, Oxidative Nitrative,Stresses, Nitro-Oxidative
D019216 Metals, Heavy Metals with high specific gravity, typically larger than 5. They have complex spectra, form colored salts and double salts, have a low electrode potential, are mainly amphoteric, yield weak bases and weak acids, and are oxidizing or reducing agents (From Grant & Hackh's Chemical Dictionary, 5th ed) Heavy Metal,Heavy Metals,Metal, Heavy

Related Publications

Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
January 2012, Methods in molecular biology (Clifton, N.J.),
Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
January 1991, Progress in histochemistry and cytochemistry,
Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
March 1990, The Medical clinics of North America,
Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
April 2002, Nihon eiseigaku zasshi. Japanese journal of hygiene,
Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
January 2020, Journal of the American College of Nutrition,
Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
February 2019, Environmental health : a global access science source,
Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
May 1979, Science (New York, N.Y.),
Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
November 2022, World journal of microbiology & biotechnology,
Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
July 2021, Antioxidants (Basel, Switzerland),
Fuli Zheng, and Filipe Marques Gonçalves, and Yumi Abiko, and Huangyuan Li, and Yoshito Kumagai, and Michael Aschner
February 2018, Current opinion in toxicology,
Copied contents to your clipboard!