-transparent.png){kind=logo}
The kinetics of cholinesterase enzymatic hydrolysis of carboxylic acid adamantyl derivatives was studied in vitro. The maximal rate of enzymatic hydrolysis in the series of bis-esters was shown to increase on elongation of the distance between ester groups. The maximal hydrolysis rate in the series of bis- and mono-esters decreases on elongation of the distance between ester group and quaternary nitrogen atom. The addition of adamantyl radical to the alcohol part of the molecule of bis- and mono-esters prevents the hydrolysis. The addition of lipophilic radicals to the cationic group of derivatives of mono- and dicarboxylic acids exerts a greater effect on the maximal hydrolysis rate in monoesters than in bis-esters.
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
December 1962,
British journal of pharmacology and chemotherapy,
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
March 1986,
Biochemical pharmacology,
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
January 1982,
Doklady Akademii nauk SSSR,
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
May 1977,
Life sciences,
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
January 1969,
Biokhimiia (Moscow, Russia),
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
January 1971,
Doklady Akademii nauk SSSR,
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
September 1972,
Antibiotiki,
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
April 1973,
Human heredity,
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
January 1972,
Biokhimiia (Moscow, Russia),
N D Igumnova, and
E Iu Lemina, and
I I Bitiukova, and
N V Klimova, and
A P Skoldinov
December 1972,
Biochimica et biophysica acta,
