BIOMAT Database Logo BIOMAT Database Logo

Human pituitary adenomas do not overexpress thec-erbB-2 oncoprotein. 1991

M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
Department of Pathology, University of Newcastle upon Tyne, England.

Thec-erbB-2 proto-oncogene encodes a 190-kD putative membrane receptor that shows considerable homology to the epidermal growth factor (EGF) receptor.c-erbB-2 is overexpressed in many human tumors but has not previously been studied in pituitary tumors. In the normal pituitary gland, EGF is believed to play a regulatory role, but EGF receptors were found to be absent in a study of 22 pituitary adenomas. In the present study, 32 human pituitary adenomas and 7 samples of normal human pituitary were stained for thec-erbB-2 oncoprotein. All were negative for membrane staining, which suggests that amplification of thec-erbB-2 oncogene is not important in the etiology and progression of human pituitary adenomas.

UI MeSH Term Description Entries

Related Publications

M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
c-erbB-2 oncoprotein expression in primary human tumors.
January 1990, Cancer,
M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
Expression of c-erbB-2 oncoprotein in human thyroid tumours.
January 1999, Histopathology,
M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
Pattern of expression of c-erbB-2 oncoprotein in human fetuses.
July 1989, British journal of cancer,
M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
Measurement of erbB-2 oncoprotein in human breast cancers by ELISA.
February 1992, Biochemical Society transactions,
M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
Multisite phosphotyping of the ErbB-2 oncoprotein in human breast cancer.
March 2001, Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology,
M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
C-erbB-2 oncoprotein immunostaining in serous effusions.
January 1993, Cytopathology : official journal of the British Society for Clinical Cytology,
M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
Expression of the c-erbB-2 (HER-2/neu) oncoprotein in human prostatic carcinoma.
November 1993, The Journal of urology,
M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2.
June 1990, Oncogene,
M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.
April 1989, Cancer research,
M R B Wetherall, and I P Corbett, and P Ince, and R A James, and M Daniels, and P E Harris, and P Kendall-Taylor
Expression of c-erbB-2 oncoprotein in primary human tumors: an immunohistochemistry study.
December 1993, Asian Pacific journal of allergy and immunology,
Copied contents to your clipboard!