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Urinary diversion into the gastrointestinal tract (ureterosigmoidostomy) is associated with stepwise malignant degeneration of colonic mucosa. Early detection of such malignancy can be difficult. Ornithine decarboxylase (ODC) is an enzyme that initiates polyamine synthesis that is elevated in malignant colonic mucosa, but its level in premalignant mucosa after ureterosigmoidostomy is unknown. Ten Wistar rats underwent urinary diversion (bladder trigone to sigmoid colon), and were maintained on a regular diet with antibiotics for 6 months, then killed. All animals developed metaplastic changes histologically at the anastomosis. Mean ODC levels of colonic mucosa at the anastomosis v normal colon 8 cm proximal were 515 +/- 177 pmole v 24.5 +/- 4.4 (P less than .01). These data show that premalignant changes in colonic mucosa after ureterosigmoidostomy can be detected by elevated colonic biopsy ODC levels. Periodic sigmoidoscopy with colon mucosa biopsy for histology and ODC levels in children with ureterosigmoidostomy is recommended.
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
July 1996,
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies,
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
November 1999,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
March 1992,
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
January 1993,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
September 1987,
The American journal of physiology,
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
August 1988,
Journal of surgical oncology,
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
January 1985,
Carcinogenesis,
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
August 1988,
Japanese journal of cancer research : Gann,
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
August 1986,
Japanese journal of cancer research : Gann,
T R Weber, and
S H Westfall, and
G F Steinhardt, and
L Webb, and
C Sotelo-Avila, and
R H Connors
January 1974,
Molecular pharmacology,
