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The extremely rare immunocytoma with IgD-paraproteinemia was observed in a 65-year-old man with infiltrations of the throat and the sinuses. The diagnosis was made on the basis of several biopsy specimens and serum immunoelectrophoresis. In spite of intensive chemotherapy and radiotherapy a remission was not achieved. In the final stages, a transformation into an immunoblastic sarcoma accompanied by an acute plasma-cell leukemia appeared. The patient died 11 months after diagnosis from renal failure due to infiltrations of the kidneys. The poor prognosis and the poor response to radiotherapy may be associated with the IgD-paraproteinemia. Serum electrophoresis and immunoelectrophoresis proved to be sensitive parameters for monitoring tumor recurrence.
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C Eisenhut, and
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