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5-Aminosalicylic acid in patients with ulcerative colitis in remission: plasma levels after administration of a new rectal enema. 1988
P Gionchetti, and
A Belluzzi, and
M Campieri, and
F Torresan, and
G M Tabanelli, and
C Brignola, and
M Miglioli, and
L Barbara
Istituto di Clinica Medica e Gastroenterologia, Policlinico S. Orsola, Bologna, Italy.
Plasma levels of total 5-aminosalicylic acid (5-ASA) were determined after a single administration of 2 g and 4 g 5-ASA enemas to 6 patients with ulcerative colitis. The mean plasma levels and AUC values confirmed that the active substance is poorly absorbed by rectal route.
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