BIOMAT Database Logo BIOMAT Database Logo

Streptozotocin-induced diabetes in rat. II. Lipid and lipid peroxide changes of lipoprotein fractions in diabetes complicated by hypertension and myocardial infarction. 1988

L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
Institute of Endocrinology and Gerontology, Bulgarian Medical Academy, Sofia.

Lipid peroxide levels and plasma lipids were studied in plasma lipoprotein fractions of streptozotocin diabetic rats, spontaneous hypertensive rats (SHR) + diabetes, and in myocardial infarction rats (MIR) + diabetes. The duration of diabetes in all experimental groups was 2.5 months. We found a tendency of elevation of cholesterol in VLDL and fall in HDL2 but the differences were not significant. Total plasma triglycerides were increased in the three diabetic groups, and the increase was due to LDL fraction but again the differences were not significant. The lipid peroxide (LP) level in total plasma showed a significant increase in the three diabetic groups: in Wistar diabetic rats LP increased 3 times, in MIR + diabetes 3.5 times, and in SHR + diabetes 5 times. The increase of LP in the three diabetic groups was due to LDL with good correlation (r = 0.60) between LP and triglycerides in LDL of the three diabetic groups. The results are in agreement with the concept of the importance of lipoprotein fraction changes: increased cholesterol, triglycerides and lipid peroxides in atherogenic (VLDL and LDL) fractions, and decreased levels in antiatherogenic (HDL, HDL2) fractions in diabetes mellitus.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008054 Lipid Peroxides Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension. Fatty Acid Hydroperoxide,Lipid Peroxide,Lipoperoxide,Fatty Acid Hydroperoxides,Lipid Hydroperoxide,Lipoperoxides,Acid Hydroperoxide, Fatty,Acid Hydroperoxides, Fatty,Hydroperoxide, Fatty Acid,Hydroperoxide, Lipid,Hydroperoxides, Fatty Acid,Peroxide, Lipid,Peroxides, Lipid
D008074 Lipoproteins Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes. Circulating Lipoproteins,Lipoprotein,Lipoproteins, Circulating
D008297 Male Males
D009203 Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). Cardiovascular Stroke,Heart Attack,Myocardial Infarct,Cardiovascular Strokes,Heart Attacks,Infarct, Myocardial,Infarction, Myocardial,Infarctions, Myocardial,Infarcts, Myocardial,Myocardial Infarctions,Myocardial Infarcts,Stroke, Cardiovascular,Strokes, Cardiovascular
D011918 Rats, Inbred SHR A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. Rats, Spontaneously Hypertensive,Rats, SHR,Inbred SHR Rat,Inbred SHR Rats,Rat, Inbred SHR,Rat, SHR,Rat, Spontaneously Hypertensive,SHR Rat,SHR Rat, Inbred,SHR Rats,SHR Rats, Inbred,Spontaneously Hypertensive Rat,Spontaneously Hypertensive Rats
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
Diabetes mellitus and hypertension complicated by myocardial infarction.
September 1971, Nursing mirror and midwives journal,
L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
Age-dependent changes in lipid peroxide levels in the lipoprotein fractions of human serum.
May 1984, Journal of gerontology,
L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
[Lipid peroxide dynamics in lipoprotein fractions and its clinical significance].
December 1983, Igaku kenkyu. Acta medica,
L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
Lipid peroxide levels of serum lipoprotein fractions of diabetic patients.
June 1981, Biochemical medicine,
L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
[Lipoprotein lipase activity and blood lipid fractions in hypertension].
January 1973, Vutreshni bolesti,
L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
Hypertension induced by streptozotocin in the rat.
May 1978, Japanese circulation journal,
L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
Lipid peroxides and alpha-tocopherol in rat streptozotocin-induced diabetes mellitus.
June 1982, Acta medica Okayama,
L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
The changes in plasma lipoproteins in rat with diabetes induced by streptozotocin.
January 1988, Journal of Tongji Medical University = Tong ji yi ke da xue xue bao,
L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
Subhuman primate pregnancy complicated by streptozotocin-induced diabetes mellitus.
April 1972, The Journal of clinical investigation,
L Somova, and A Kirjakov, and G Dashev, and M Doncheva, and M Vassileva, and G Tchoneva, and S Valkova
[First findings or lipid and lipoprotein changes induced by prednisone in diabetes mellitus].
July 1956, Rassegna di fisiopatologia clinica e terapeutica,
Copied contents to your clipboard!