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Interpreting technetium-99m pyrophosphate cardiac scans to diagnose transthyretin cardiac amyloidosis: Need for due diligence. 2021

Brian Butera, and Diane Klingler, and James K Mccord, and Karthik Ananthasubramaniam
Heart and Vascular Institute, Henry Ford West Bloomfield Hospital, 6777 West Maple, West Bloomfield, MI, 48322, USA.

UI MeSH Term Description Entries
D008297 Male Males
D009202 Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS). Myocardial Disease,Myocardial Diseases,Myocardial Diseases, Primary,Myocardial Diseases, Secondary,Myocardiopathies,Primary Myocardial Disease,Cardiomyopathies, Primary,Cardiomyopathies, Secondary,Primary Myocardial Diseases,Secondary Myocardial Diseases,Cardiomyopathy,Cardiomyopathy, Primary,Cardiomyopathy, Secondary,Disease, Myocardial,Disease, Primary Myocardial,Disease, Secondary Myocardial,Diseases, Myocardial,Diseases, Primary Myocardial,Diseases, Secondary Myocardial,Myocardial Disease, Primary,Myocardial Disease, Secondary,Myocardiopathy,Primary Cardiomyopathies,Primary Cardiomyopathy,Secondary Cardiomyopathies,Secondary Cardiomyopathy,Secondary Myocardial Disease
D003951 Diagnostic Errors Incorrect or incomplete diagnoses following clinical or technical diagnostic procedures. Diagnostic Blind Spots,Errors, Diagnostic,Misdiagnosis,Blind Spot, Diagnostic,Blind Spots, Diagnostic,Diagnostic Blind Spot,Diagnostic Error,Error, Diagnostic,Misdiagnoses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D015899 Tomography, Emission-Computed, Single-Photon A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image. CAT Scan, Single-Photon Emission,CT Scan, Single-Photon Emission,Radionuclide Tomography, Single-Photon Emission-Computed,SPECT,Single-Photon Emission-Computed Tomography,Tomography, Single-Photon, Emission-Computed,Single-Photon Emission CT Scan,Single-Photon Emission Computer-Assisted Tomography,Single-Photon Emission Computerized Tomography,CAT Scan, Single Photon Emission,CT Scan, Single Photon Emission,Emission-Computed Tomography, Single-Photon,Radionuclide Tomography, Single Photon Emission Computed,Single Photon Emission CT Scan,Single Photon Emission Computed Tomography,Single Photon Emission Computer Assisted Tomography,Single Photon Emission Computerized Tomography,Tomography, Single-Photon Emission-Computed
D016698 Technetium Tc 99m Pyrophosphate A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities. Tc 99m-Pyrophosphate,99mTc-Pyrophosphate,Diphosphoric Acid, Technetium Salt,Tc-PYP,Technetium Tc 99m Pyrophosphate, Tc(3+) Salt (3:4),Technetium Tc 99m Pyrophosphate, Tc(4+) Salt (1:1),99mTc Pyrophosphate,Tc 99m Pyrophosphate,Tc PYP
D019275 Radiopharmaceuticals Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) Radiopharmaceutical
D028227 Amyloid Neuropathies, Familial Inherited disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. The different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (PREALBUMIN); APOLIPOPROTEIN A-I; and GELSOLIN. Familial Amyloid Polyneuropathies,Amyloid Neuropathy Type 1,Amyloid Polyneuropathy, British Type,Amyloid Polyneuropathy, Iowa Type,Amyloid Polyneuropathy, Swiss Type,Appalachian Type Familial Amyloid Polyneuropathy,British Type Amyloid Polyneuropathy,Cerebral Amyloid Angiopathy, British Type,Familial Amyloid Neuropathy, Andrade Type,Familial Amyloid Neuropathy, Finnish Type,Familial Amyloid Neuropathy, Portuguese Type,Familial Amyloid Polyneuropathy, Appalachian Type,Familial Amyloid Polyneuropathy, Jewish Type,Familial Amyloid Polyneuropathy, Type I,Familial Amyloid Polyneuropathy, Type II,Familial Amyloid Polyneuropathy, Type III,Familial Amyloid Polyneuropathy, Type IV,Familial Amyloid Polyneuropathy, Type V,Familial Amyloid Polyneuropathy, Type VI,Familial Portuguese Polyneuritic Amyloidosis,Finnish Type Familial Amyloid Neuropathy,Hereditary Neuropathic Amyloidosis,Iowa Type Amyloid Polyneuropathy,Jewish Type Familial Amyloid Polyneuropathy,Neuropathic Amyloid Syndrome,Polyneuritic Amyloidosis, Portuguese,Portuguese Polyneuritic Amyloidosis,Portuguese Type Familial Amyloid Neuropathy,Swiss Type Amyloid Polyneuropathy,Type I Familial Amyloid Polyneuropathy,Type II Familial Amyloid Polyneuropathy,Type III Familial Amyloid Polyneuropathy,Type IV Familial Amyloid Polyneuropathy,Type V Familial Amyloid Polyneuropathy,Type VI Familial Amyloid Polyneuropathy,Wohlwill-Andrade Syndrome,Wohlwill-Corino Andrade Syndrome,Amyloid Neuropathy, Familial,Amyloid Polyneuropathies, Familial,Amyloid Polyneuropathy, Familial,Amyloid Syndrome, Neuropathic,Amyloid Syndromes, Neuropathic,Amyloidoses, Hereditary Neuropathic,Amyloidoses, Portuguese Polyneuritic,Amyloidosis, Hereditary Neuropathic,Amyloidosis, Portuguese Polyneuritic,Familial Amyloid Neuropathies,Familial Amyloid Neuropathy,Familial Amyloid Polyneuropathy,Hereditary Neuropathic Amyloidoses,Neuropathic Amyloid Syndromes,Neuropathic Amyloidoses, Hereditary,Neuropathic Amyloidosis, Hereditary,Neuropathies, Familial Amyloid,Neuropathy, Familial Amyloid,Polyneuritic Amyloidoses, Portuguese,Polyneuropathies, Familial Amyloid,Polyneuropathy, Familial Amyloid,Portuguese Polyneuritic Amyloidoses,Wohlwill Andrade Syndrome,Wohlwill Corino Andrade Syndrome

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