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Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. 2020

Bei Gao, and Atoosa Emami, and Rongrong Zhou, and Sonja Lang, and Yi Duan, and Yanhan Wang, and Lu Jiang, and Rohit Loomba, and David A Brenner, and Peter Stärkel, and Bernd Schnabl
Department of Medicine, University of California, San Diego, San Diego, CA, United States.

Excessive alcohol consumption is associated with hepatic steatosis and dysregulation of the gut microbiota in patients with alcohol use disorder (AUD). However, how gut microbiota responds when patients stop drinking has not been well studied. In this study, we use shotgun metagenomic sequencing to elucidate the alterations in the functional capacity of gut microbiota in patients with AUD when they stop drinking for 2-weeks. Sensitive microbial pathways to alcohol abstinence were identified in AUD patients. Further, we found the functional microbial responses to alcohol abstinence were different in AUD patients with different degree of hepatic steatosis. Our results provide insights into the link between functional alterations of the gut microbiota and steatosis associated with alcohol consumption.

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