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Pd(II)-Catalyzed Tandem Enantioselective Methylene C(sp3 )-H Alkenylation-Aza-Wacker Cyclization to Access β-Stereogenic γ-Lactams. 2020
Yi Ding, and
Ye-Qiang Han, and
Le-Song Wu, and
Tao Zhou, and
Qi-Jun Yao, and
Ya-Lan Feng, and
Ya Li, and
Ke-Xin Kong, and
Bing-Feng Shi
Department of Chemistry, Zhejiang University, Hangzhou, 310027, China.
Herein, we describe an unprecedented cascade reaction to β-stereogenic γ-lactams involving Pd(II)-catalyzed enantioselective aliphatic methylene C(sp3 )-H alkenylation-aza-Wacker cyclization through syn-aminopalladation. Readily available 3,3'-substituted BINOLs are used as chiral ligands, providing the corresponding γ-lactams with broad scope and high enantioselectivities (up to 98 % ee).
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