-transparent.png){kind=logo}
The transfer of drugs from the mother to the fetus is important from the view of possible harmful as well as therapeutic effects on both mother and fetus. In the first trimester of pregnancy this has been sparsely investigated. In 66 first-trimester pregnant women, who had applied for legal termination of the pregnancy, we have calculated different pharmacokinetic parameters of two benzodiazepine derivatives, diazepam and oxazepam, after administration of a single oral dose of 10 or 25 mg to the mother. The calculated pharmacokinetic parameters were within the normal range for healthy adults. The pharmacological active metabolite n-desmethyldiazepam was measured in concentrations near the detection limit. The penetration of diazepam and oxazepam from maternal serum to placental tissue in a 4 h period after drug administration was 31.5% and 49%, respectively, indicating a rapid transfer.
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
January 1971,
Actas luso-espanolas de neurologia y psiquiatria,
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
March 1984,
Archives of general psychiatry,
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
January 1974,
Annales chirurgiae et gynaecologiae Fenniae,
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
July 1970,
Actas luso-espanolas de neurologia y psiquiatria,
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
January 1974,
Acta obstetricia et gynecologica Scandinavica,
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
February 1974,
Pharmacological research communications,
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
January 1988,
European journal of clinical pharmacology,
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
October 1976,
Den Norske tannlaegeforenings tidende,
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
June 1976,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
N P Jørgensen, and
E Thurmann-Nielsen, and
R A Walstad
January 1991,
Psychopharmacology,
