[Repeated injection of atracurium for muscle relaxation in abdominal surgery]. 1988

M Leuwer, and G Klein
Zentrum der Anästhesiologie und Wiederbung Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.

21 patients selected for abdominal surgery received intravenously after initiation of neuroleptic analgesia for intubation, 0.5 mg/kg body weight (BW) of atracurium. Relaxation was maintained by repeat doses of 0.2 mg/kg BW atracurium. Both the time of intubation and the time of giving the repeat dose depended on the electromyographically measured stimulus response to supramaximal stimulation of the ulnar nerve (Datex-NTM, "Train-of-Four" stimulation). Intubation was effected at maximal inhibition of stimulus response, on the average after 195 +/- 90 sec. The duration of clinical efficacy was 33 +/- 8 min on the average, the recovery index 13 +/- 7 min and the duration of the full effect 54 +/- 6 min. The repeat doses were administered as soon as stimulus response recovered to 25% of the original value. Up to a cumulative total dose of 1.5 mg/kg BW atracurium no extension of the duration of clinical efficacy and of the full effect was seen, but there was a prolongation of the recovery index. The "Train-of-Four" quotient during recovery of relaxation was independent of the cumulative total dose. In the dosage levels described here, atracurium hardly exercised any action on pulse rate and blood pressure.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009126 Muscle Relaxation That phase of a muscle twitch during which a muscle returns to a resting position. Muscle Relaxations,Relaxation, Muscle,Relaxations, Muscle
D009469 Neuromuscular Junction The synapse between a neuron and a muscle. Myoneural Junction,Nerve-Muscle Preparation,Junction, Myoneural,Junction, Neuromuscular,Junctions, Myoneural,Junctions, Neuromuscular,Myoneural Junctions,Nerve Muscle Preparation,Nerve-Muscle Preparations,Neuromuscular Junctions,Preparation, Nerve-Muscle,Preparations, Nerve-Muscle
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004576 Electromyography Recording of the changes in electric potential of muscle by means of surface or needle electrodes. Electromyogram,Surface Electromyography,Electromyograms,Electromyographies,Electromyographies, Surface,Electromyography, Surface,Surface Electromyographies
D005260 Female Females

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