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Long-term outcome of cervical artery dissection : IPSYS CeAD: study protocol, rationale, and baseline data of an Italian multicenter research collaboration. 2020
Sonia Bonacina, and
Mario Grassi, and
Marialuisa Zedde, and
Andrea Zini, and
Anna Bersano, and
Carlo Gandolfo, and
Giorgio Silvestrelli, and
Claudio Baracchini, and
Paolo Cerrato, and
Corrado Lodigiani, and
Simona Marcheselli, and
Maurizio Paciaroni, and
Maurizia Rasura, and
Manuel Cappellari, and
Massimo Del Sette, and
Anna Cavallini, and
Andrea Morotti, and
Giuseppe Micieli, and
Enrico Maria Lotti, and
Maria Luisa DeLodovici, and
Mauro Gentile, and
Mauro Magoni, and
Cristiano Azzini, and
Maria Vittoria Calloni, and
Elisa Giorli, and
Massimiliano Braga, and
Paolo La Spina, and
Fabio Melis, and
Rossana Tassi, and
Valeria Terruso, and
Rocco Salvatore Calabrò, and
Maurizio Melis, and
Maria Sessa, and
Martina Locatelli, and
Sandro Sanguigni, and
Carla Zanferrari, and
Marina Mannino, and
Giuseppina Calabrese, and
Carlo Dallocchio, and
Patrizia Nencini, and
Valeria Bignamini, and
Alessandro Adami, and
Eugenio Magni, and
Rita Bella, and
Alessandro Padovani, and
Alessandro Pezzini, and
Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy.
Long-term consequences of cervical artery dissection (CeAD), a major cause of ischemic stroke in young people, have been poorly investigated. The Italian Project on Stroke at Young Age - Cervical Artery Dissection (IPSYS CeAD) project is a multicenter, hospital-based, consecutively recruiting, observational, cohort study aimed to address clinically important questions about long-term outcome of CeAD patients, which are not covered by other large-scale registries. Patients with radiologically diagnosed CeAD were consecutively included in the registry. Baseline demographic and clinical variables, as well as information on risk factors, were systematically collected for each eligible patient. Follow-up evaluations were conducted between 3 and 6 months after the initial event (t1) and then annually (t2 at 1 year, t3 at 2 years , and so on), in order to assess outcome events (long-term recurrent CeAD, any fatal/nonfatal ischemic stroke, transient ischemic attack (TIA), or other arterial thrombotic event, and death from any cause). Between 2000 and 2019, data from 1530 patients (age at diagnosis, 47.2 ± 11.5 years; women, 660 [43.1%]) have been collected at 39 Italian neurological centers. Dissection involved a single vessel in 1308 (85.5%) cases and caused brain ischemia in 1303 (85.1%) (190 TIA/1113 ischemic stroke). Longitudinal data are available for 1414 (92.4%) patients (median follow-up time in patients who did not experience recurrent events, 36.0 months [25th to 75th percentile, 63.0]). The collaborative IPSYS CeAD effort will provide novel information on the long-term outcome of CeAD patients. This could allow for tailored treatment approaches based on patients' individual characteristics.
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