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Development and validation of serological markers for detecting recent Plasmodium vivax infection. 2020
Rhea J Longley, and
Michael T White, and
Eizo Takashima, and
Jessica Brewster, and
Masayuki Morita, and
Matthias Harbers, and
Thomas Obadia, and
Leanne J Robinson, and
Fumie Matsuura, and
Zoe S J Liu, and
Connie S N Li-Wai-Suen, and
Wai-Hong Tham, and
Julie Healer, and
Christele Huon, and
Chetan E Chitnis, and
Wang Nguitragool, and
Wuelton Monteiro, and
Carla Proietti, and
Denise L Doolan, and
Andre M Siqueira, and
Xavier C Ding, and
Iveth J Gonzalez, and
James Kazura, and
Marcus Lacerda, and
Jetsumon Sattabongkot, and
Takafumi Tsuboi, and
Ivo Mueller
Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy.
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Connie S N Li-Wai-Suen, and
Wai-Hong Tham, and
Julie Healer, and
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Wuelton Monteiro, and
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Wai-Hong Tham, and
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Christele Huon, and
Chetan E Chitnis, and
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Wuelton Monteiro, and
Carla Proietti, and
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Andre M Siqueira, and
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James Kazura, and
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