Physically crosslinked silk fibroin/hyaluronic acid scaffolds. 2020

Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, 430200, China.

Combining the properties of natural protein and polysaccharide is a promising strategy to generate bioactive biomaterials with controlled structure. Here, a new method of preparing water-insoluble silk fibroin/hyaluronic acid (SF/HA) scaffolds with tunable performances using an all-aqueous process is reported. Freezing-induced assembly was used to form silk I crystallization in the SF/HA blends. Silk I crystallization enhanced the stability of SF/HA scaffolds in water by forming silk I crystal networks to entrap blended HA without chemical cross-linking. Increasing HA content significantly enhanced the flexibility and water binding capacity of porous scaffolds, but high amount of HA reduced the water-stability of porous scaffolds due to insufficient silk I crystal cross-links. The enzymatic degradation behavior of the SF/HA scaffolds was investigated, revealing that the regulation ability of HA in the SF scaffolds. This novel nonchemically cross-linked protein/polysaccharide scaffold may be useful for soft tissue engineering due to excellent biocompatibility and tunable performances.

UI MeSH Term Description Entries
D010316 Particle Size Relating to the size of solids. Particle Sizes,Size, Particle,Sizes, Particle
D005349 Fibroins Fibrous proteins secreted by INSECTS and SPIDERS. Generally, the term refers to silkworm fibroin secreted by the silk gland cells of SILKWORMS, Bombyx mori. Spider fibroins are called spidroins or dragline silk fibroins. Fibroin,Spidroin,Dragline Silk Fibroins,Fibroins, Spider,Silk Fibroin,Silk Fibroins,Spidroins,Fibroin, Silk,Fibroins, Dragline Silk,Fibroins, Silk,Spider Fibroins
D006820 Hyaluronic Acid A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA. Amo Vitrax,Amvisc,Biolon,Etamucine,Healon,Hyaluronan,Hyaluronate Sodium,Hyvisc,Luronit,Sodium Hyaluronate,Acid, Hyaluronic,Hyaluronate, Sodium,Vitrax, Amo
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012831 Bombyx A genus of silkworm MOTHS in the family Bombycidae of the order LEPIDOPTERA. The family contains a single species, Bombyx mori from the Greek for silkworm + mulberry tree (on which it feeds). A native of Asia, it is sometimes reared in this country. It has long been raised for its SILK and after centuries of domestication it probably does not exist in nature. It is used extensively in experimental GENETICS. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p519) Bombyx mori,Silkmoths,Silkworms,Silkmoth,Silkworm,Bombyx morus,Bombyxs,mori, Bombyx
D012995 Solubility The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Solubilities
D013499 Surface Properties Characteristics or attributes of the outer boundaries of objects, including molecules. Properties, Surface,Property, Surface,Surface Property
D014867 Water A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Hydrogen Oxide
D017364 Collagenases Enzymes that catalyze the degradation of collagen by acting on the peptide bonds. Collagen Peptidase,Collagen-Degrading Enzyme,Collagenase,Collagen Degrading Enzyme,Peptidase, Collagen
D047011 Silk A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.

Related Publications

Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
April 2010, Journal of materials science. Materials in medicine,
Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
January 2012, Journal of biomaterials science. Polymer edition,
Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
June 2013, Acta biomaterialia,
Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
July 2017, Biomaterials,
Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
March 2007, International journal of biological macromolecules,
Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
December 2010, Journal of biomedical materials research. Part A,
Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
December 2018, International journal of biological macromolecules,
Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
May 2021, Molecules (Basel, Switzerland),
Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
November 2010, Biomacromolecules,
Yupin Guan, and Haining You, and Junyi Cai, and Qiang Zhang, and Shuqin Yan, and Renchuan You
October 2018, International journal of biological macromolecules,
Copied contents to your clipboard!