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Although renal involvement is common in non-Hodgkin's lymphoma (NHL), primary renal NHL is a rare disease. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of NHL and is responsible for 30-40% of adult NHL cases globally. Here, we present a case of a 68-year-old man with right flank pain who underwent retroperitoneal laparoscopic radical nephrectomy for an enlarged right kidney, with evidence of an infiltrating mass. Postoperative histopathological examination revealed primary renal DLBCL. Primary renal lymphoma (PRL) is quite rare, and clinicians should try to ensure early diagnosis and treatment with standardized and systematic chemotherapy.
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