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To examine the diffusion of enoxacin into the prostatic fluid of patients with chronic prostatitis, the serum level and the expressed prostatic secretion (EPS) level of enoxacin were measured. Enoxacin was administered orally at a dose of 200 mg in 24 chronic prostatitis patients. One hour later, blood and EPS samples were taken. The level of enoxacin was measured by the bioassay using E. coli (Kp strain). In 24 patients, the mean value of enoxacin was 1.24 micrograms/ml in the serum and 0.69 micrograms/ml in the EPS. The mean ratio of EPS/serum was 0.58. These results indicated that enoxacin diffused well into the prostatic fluid of chronic prostatitis patients.
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