Secretory IgA levels in normal and atopic individuals. Influence of breast and/or bottle feeding. 1988

D Solé, and M M Zaha, and P G Leser, and C K Naspitz
Section of Allergy, Clinical Immunology and Rheumatology, Escola Paulista de Medicina, São Paulo, Brazil.

The SIgA and IgA quantification by radial immunodiffusion was carried out in the saliva of 449 normal individuals, whose ages vary from 1 day to 32 years old. SIgA was determined in an agar plate containing purified serum against SIgA of human colostrum and the IgA in commercial plates containing serum anti IgA. The SIgA values grouped in different age groups were much variable, allowing only to establish minimum critical values for each group. In the saliva of 71 patients IgA was dosed by both methods. The set of obtained data showed significant correlation (p less than 0.05). The dosage of standardized quantities of SIgA and IgA in conventional plates containing serum anti IgA, allowed to establish corresponding values similar to precipitation ring diameter. In this way, it was possible to establish a "critical value" for salivary IgA by the use of conventional plates. Thus, the IgA quantitative determination by radial immunodiffusion with antibody against serum IgA was carried out in saliva samples of normal and atopic individuals (asthma and/or rhinitis). The patients' ages varied from 1 month to 32 years old. The obtained values were grouped according to defined age group. We observed non-measurable values in 70% of the children aged less than 1 month; from then on, the values were increasing, reaching adult levels from the 6th year on. We did not observe differences between the salivary IgA levels of normal and atopic children. In children aged less than 6 months breast and/or bottle feeding (natural, mixed or artificial) there were no differences between the IgA levels observed in saliva.

UI MeSH Term Description Entries
D006969 Hypersensitivity, Immediate Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability. Atopic Hypersensitivity,Hypersensitivity, Atopic,Hypersensitivity, Type I,IgE-Mediated Hypersensitivity,Type I Hypersensitivity,Atopic Hypersensitivities,Hypersensitivities, Atopic,Hypersensitivities, IgE-Mediated,Hypersensitivities, Immediate,Hypersensitivities, Type I,Hypersensitivity, IgE-Mediated,IgE Mediated Hypersensitivity,IgE-Mediated Hypersensitivities,Immediate Hypersensitivities,Immediate Hypersensitivity,Type I Hypersensitivities
D007070 Immunoglobulin A Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions. IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007071 Immunoglobulin A, Secretory The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS). Colostral IgA,IgA, Exocrine,IgA, Secretory,SIgA,Secretory IgA,Secretory Immunoglobulin A,Exocrine IgA,IgA, Colostral
D007223 Infant A child between 1 and 23 months of age. Infants
D007225 Infant Food Food processed and manufactured for the nutritional health of children in their first year of life. Food, Infant,Foods, Infant,Infant Foods
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D012130 Respiratory Hypersensitivity A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL. Airway Hyperresponsiveness,Hypersensitivity, Respiratory,Airway Hyper-Responsiveness,Airway Hyper Responsiveness,Airway Hyperresponsivenesses,Hyper-Responsiveness, Airway,Hyperresponsiveness, Airway,Respiratory Hypersensitivities
D001942 Breast Feeding The nursing of an infant at the breast. Breast Fed,Breastfed,Milk Sharing,Wet Nursing,Breast Feeding, Exclusive,Breastfeeding,Breastfeeding, Exclusive,Exclusive Breast Feeding,Exclusive Breastfeeding,Sharing, Milk
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children

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