Toripalimab-Induced Dermatomyositis in a Patient with Metastatic Melanoma. 2020

Jingrong Lin, and Minmin Xue, and Mingyang Gao, and Pu Yu, and Shixin Han
Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China.

Toripalimab is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). It has recently been approved as an immune checkpoint inhibitor in second-line therapies in patients with unresectable or metastatic melanoma; however, it may be associated with various immune-related adverse events (irAEs). Here we report a case of toripalimab-induced dermatomyositis in a patient receiving treatment for metastatic melanoma. The symptoms were relieved by discontinuing toripalimab and administering once-daily intravenous methylprednisolone 1 mg/kg. We suggest that this case serves a warning to clinicians of the need to be aware of the possiblilty of toripalimab-induced dermatomyositis. Early recognition and treatment may prevent progression and improve prognosis of this irAE.

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