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Serum cystatin C (CysC) is a promising biomarker of kidney function, which has higher accuracy and sensitivity when compared with creatinine. To better utilize serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC. The study subjects consisted of healthy term neonates and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunoturbidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs. A total of 378 samples with equal numbers of males and females were analysed for serum CysC. No outliers were found in this analysis. The continuous RIs are presented as equations and graphical scatterplots. This study established continuous paediatric reference intervals (RIs) for serum CysC in healthy term neonates and children. The continuous RIs generated from this study show age-based dynamic changes as well as blood group and gender-specific differences for serum CysC. Graphical abstract.
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
February 2014,
Pediatric nephrology (Berlin, Germany),
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
July 2019,
The Journal of international medical research,
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
October 2013,
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians,
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
October 2019,
Clinical chemistry,
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
June 1998,
Clinical chemistry and laboratory medicine,
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
January 2007,
Clinical chemistry and laboratory medicine,
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
July 2013,
Pediatric nephrology (Berlin, Germany),
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
January 2011,
West African journal of medicine,
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
October 1999,
Clinical chemistry,
Tengyi Cai, and
Vasiliki Karlaftis, and
Stephen Hearps, and
Susan Matthews, and
Janet Burgess, and
Paul Monagle, and
Vera Ignjatovic, and
September 2011,
Clinical biochemistry,
