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Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling. 2020
Xiaomei I Liu, and
Jeremiah D Momper, and
Natella Y Rakhmanina, and
Dionna J Green, and
Gilbert J Burckart, and
Tim R Cressey, and
Mark Mirochnick, and
Brookie M Best, and
John N van den Anker, and
André Dallmann
Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA. rph5862@gmail.com.
Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal-fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir.
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