Biomaterial Database

Intravascular volume expansion and fetal outcome in pregnant Nigerians with hemoglobin SS and SC. 1988

O O Abudu, and O A Sofola

In a comparative study of physiological changes in pregnant Nigerians, plasma volume measurements were performed in 75 healthy Nigerian women. They comprised 40 women with hemoglobin genotype AA (20 pregnant and 20 nonpregnant) and 35 women with hemoglobin genotype SS or SC (15 pregnant and 20 nonpregnant). Plasma volume was determined in the left lateral position using the Evans blue dye dilution technique (described by Dacie and Lewis) in the nonpregnant, at 16 and 36 weeks of gestation, and at 8 weeks postpartum.The mean plasma volume of 2044 ± 77.4 mL (SEM) in normal nonpregnant women with Hb AA was not significantly different from the mean plasma volume of 1931 ± 115 mL (SEM) found in nonpregnant sicklers. At 16 weeks' gestation there was no significant difference in the mean plasma volume of 2712 ± 209.8 mL (SEM) in pregnant women with HB AA and 2948 ± 165.8 mL (SEM) in pregnant sicklers. However, at 36 weeks the mean plasma volume of 3440 ± 223.7 mL (SEM) (68 percent increase compared with nonpregnant) in pregnant women with Hb AA was significantly higher (P < .02) than the mean plasma volume of 2312 ± 214.8 mL (SEM) (17 percent increase compared with nonpregnant) in sicklers.The mean birthweight of 3.17 ± 0.08 kg (SEM) in women with Hb AA was higher (P < .01) than that of 2.58 ± 0.15 kg (SEM) in sicklers. The perinatal mortality in sicklers was 133/thousand total births, while there was no fetal loss in the control. These data suggest a decrease or lack of intravascular volume expansion and evidence of uteroplacental insufficiency in sicklers.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D009549	Nigeria	A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.	Federal Republic of Nigeria
D010953	Plasma Volume	Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES.	Blood Plasma Volume,Blood Plasma Volumes,Plasma Volumes,Volume, Blood Plasma,Volume, Plasma,Volumes, Blood Plasma,Volumes, Plasma
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011250	Pregnancy Complications, Hematologic	The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.	Complications, Hematologic Pregnancy,Hematologic Pregnancy Complications,Pregnancy Complications, Hematological,Pregnancy, Hematologic Complications,Complication, Hematologic Pregnancy,Complication, Hematological Pregnancy,Complications, Hematological Pregnancy,Hematologic Pregnancy Complication,Hematological Pregnancy Complication,Hematological Pregnancy Complications,Pregnancies, Hematologic Complications,Pregnancy Complication, Hematologic,Pregnancy Complication, Hematological
D011256	Pregnancy Outcome	Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; or SPONTANEOUS ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.	Outcome, Pregnancy,Outcomes, Pregnancy,Pregnancy Outcomes
D005260	Female		Females
D006400	Hematocrit	The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.	Erythrocyte Volume, Packed,Packed Red-Cell Volume,Erythrocyte Volumes, Packed,Hematocrits,Packed Erythrocyte Volume,Packed Erythrocyte Volumes,Packed Red Cell Volume,Packed Red-Cell Volumes,Red-Cell Volume, Packed,Red-Cell Volumes, Packed,Volume, Packed Erythrocyte,Volume, Packed Red-Cell,Volumes, Packed Erythrocyte,Volumes, Packed Red-Cell
D006450	Hemoglobin SC Disease	One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.	SC Disease,Sickle Cell Hemoglobin C Disease,Disease, Hemoglobin SC,Disease, SC,Diseases, Hemoglobin SC,Diseases, SC,Hemoglobin SC Diseases,SC Disease, Hemoglobin,SC Diseases,SC Diseases, Hemoglobin
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man