[Characteristics of the clinical picture, hormonal status and humoral immunity in older patients with diffuse toxic goiter]. 1988

V V Natarov, and T S Grinchenko, and N I Afanas'eva, and P M Pesotskaia, and V M Nikolaeva

Radioimmunoassays, immunological and radioreceptor methods were used for a study of the levels of T3, T4, TSH, thyroglobulin, antibodies to thyroglobulin and microsomal antigen, immunoglobulins suppressing thyrotropin binding in 92 patients with diffuse toxic goiter aged over 50. There was discrepancy between the prevalence of severe types of disease in this group of patients and an insignificant rise of T3 and T4 levels. Changes in the immune status pointed to an increase in immunodeficiency which became progressive with aging of the organism, and increasing sensitivity to damaging agents.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006111 Graves Disease A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). Basedow's Disease,Exophthalmic Goiter,Goiter, Exophthalmic,Graves' Disease,Basedow Disease,Hyperthyroidism, Autoimmune,Basedows Disease,Disease, Basedow,Disease, Basedow's,Disease, Graves,Disease, Graves',Exophthalmic Goiters,Goiters, Exophthalmic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000917 Antibody Formation The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS. Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D001323 Autoantibodies Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them. Autoantibody
D013954 Thyroglobulin

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