BIOMAT Database Logo BIOMAT Database Logo

Postnatal Involution and Counter-Involution of the Thymus. 2020

Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration.

UI MeSH Term Description Entries
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D004847 Epithelial Cells Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells. Adenomatous Epithelial Cells,Columnar Glandular Epithelial Cells,Cuboidal Glandular Epithelial Cells,Glandular Epithelial Cells,Squamous Cells,Squamous Epithelial Cells,Transitional Epithelial Cells,Adenomatous Epithelial Cell,Cell, Adenomatous Epithelial,Cell, Epithelial,Cell, Glandular Epithelial,Cell, Squamous,Cell, Squamous Epithelial,Cell, Transitional Epithelial,Cells, Adenomatous Epithelial,Cells, Epithelial,Cells, Glandular Epithelial,Cells, Squamous,Cells, Squamous Epithelial,Cells, Transitional Epithelial,Epithelial Cell,Epithelial Cell, Adenomatous,Epithelial Cell, Glandular,Epithelial Cell, Squamous,Epithelial Cell, Transitional,Epithelial Cells, Adenomatous,Epithelial Cells, Glandular,Epithelial Cells, Squamous,Epithelial Cells, Transitional,Glandular Epithelial Cell,Squamous Cell,Squamous Epithelial Cell,Transitional Epithelial Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013234 Stem Cells Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells. Colony-Forming Units,Mother Cells,Progenitor Cells,Colony-Forming Unit,Cell, Mother,Cell, Progenitor,Cell, Stem,Cells, Mother,Cells, Progenitor,Cells, Stem,Colony Forming Unit,Colony Forming Units,Mother Cell,Progenitor Cell,Stem Cell
D013950 Thymus Gland A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat. Thymus,Gland, Thymus,Glands, Thymus,Thymus Glands
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
Involution and neoplasms of the thymus.
January 2000, In vivo (Athens, Greece),
Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
Involution of the human thymus.
April 1967, The Journal of pathology and bacteriology,
Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
Evolution, development and involution of the thymus.
January 1998, Folia microbiologica,
Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
[Normal and accidental involution of the thymus].
January 1969, Annales d'endocrinologie,
Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
The thymus involution assay of corticotrophin.
May 1962, Acta endocrinologica,
Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
"Accidental" involution of the human thymus.
October 1968, The Journal of pathology and bacteriology,
Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
The bovine cervical thymus and its involution.
May 1949, Upsala lakareforenings forhandlingar,
Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
The thymus involution test for ACTH.
January 1953, Acta endocrinologica,
Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
Thymus Involution and Intravenous Drug Abuse.
March 2020, The American journal of forensic medicine and pathology,
Jennifer E Cowan, and Yousuke Takahama, and Avinash Bhandoola, and Izumi Ohigashi
Involution of the thymus dependent lymphoid system.
January 1973, Advances in experimental medicine and biology,
Copied contents to your clipboard!