Biomaterial Database

[Correlation between nasopharyngeal carcinoma and HLA in Sichuan]. 1988

B W Yuan

West China University of Medical Sciences, Chengdu.

Fifty three cases of nasopharyngeal carcinoma (NPC) in Sichuan and 212 normal individuals in our University were studied for their human Leucocyte antigen(HLA) typing by the standard NIH microcytotoxicity test. A total of 135 antisera which could defined 44 specificities of HLA-A, B and DR loci were used for this purpose. In this paper, BW46 and DR antigens for detecting NPC patients is reported at home for the first time. The results showed that there existed a strong correlation between BW46 and NPC (RR = 7.19, chi 2 = 18.10, Pc less than 0.05) and an apparent negative association between A11 and NPC (RR = 0.36, chi 2 = 9.79, Pc less than 0.05). The gene frequency of DR blank in patients was much higher than that in the controls (Pc less than 0.05). B17 frequency in patients was also higher than that in the controls (chi 2 = 6.85). Even though the Fisher P value was less than 0.01, it was insignificant after being corrected. There was no significant difference between the patients and controls in our data A2, A9 and AW19.

UI	MeSH Term	Description	Entries
D009303	Nasopharyngeal Neoplasms	Tumors or cancer of the NASOPHARYNX.	Cancer of Nasopharynx,Nasopharyngeal Cancer,Cancer of the Nasopharynx,Nasopharynx Cancer,Nasopharynx Neoplasms,Neoplasms, Nasopharyngeal,Cancer, Nasopharyngeal,Cancer, Nasopharynx,Cancers, Nasopharyngeal,Cancers, Nasopharynx,Nasopharyngeal Cancers,Nasopharyngeal Neoplasm,Nasopharynx Cancers,Nasopharynx Neoplasm,Neoplasm, Nasopharyngeal,Neoplasm, Nasopharynx,Neoplasms, Nasopharynx
D006680	HLA Antigens	Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.	Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006684	HLA-DR Antigens	A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.	HLA-DR,Antigens, HLA-DR,HLA DR Antigens
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015234	HLA-A Antigens	Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.	Antigens, HLA-A,HLA-A,Antigens, HLA A,HLA A Antigens
D015235	HLA-B Antigens	Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.	Antigens, HLA-B,HLA-B Antigen,HLA-B,Antigen, HLA-B,Antigens, HLA B,HLA B Antigen,HLA B Antigens
D059870	HLA-A11 Antigen	A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*11 allele family.	HLA A11,HLA Class I Histocompatibility Antigen, A-11 alpha Chain,HLA-A11,HLA Class I Histocompatibility Antigen, A 11 alpha Chain