-transparent.png){kind=logo}
3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities. 1988
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
The synthesis of N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives (V) by reaction of primary and secondary amines with the tosylates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative is described. Some of compounds (V) showed a remarkable analgesic activity in mice. Moreover, the above compounds usually exhibited moderate hypotensive, bradycardiac and antiinflammatory activities in rats, infiltration anesthesia in mice, as well as a weak platelet antiaggregating activity in vitro.
Related Publications
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
January 2015,
Acta crystallographica. Section C, Structural chemistry,
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
December 2011,
Acta crystallographica. Section E, Structure reports online,
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
May 2012,
Acta crystallographica. Section E, Structure reports online,
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
April 1993,
Farmaco (Societa chimica italiana : 1989),
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
April 2008,
Archiv der Pharmazie,
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
February 1990,
Farmaco (Societa chimica italiana : 1989),
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
February 2011,
Acta crystallographica. Section E, Structure reports online,
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
January 1993,
Drug design and discovery,
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
May 2010,
Acta crystallographica. Section E, Structure reports online,
F Bondavalli, and
O Bruno, and
A Ranise, and
P Schenone, and
S Russo, and
A Loffreda, and
V De Novellis, and
C Lo Sasso, and
E Marmo
January 2010,
Acta crystallographica. Section E, Structure reports online,
