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[Synthesis, antisecretory, and anti-ulcer activity of new 5-arylidene-2-ureidoalkyl-3-pyridazinones]. 1988
Laboratoire de Chimie Thérapeutique, Groupede Recherche en Pharmacochimie, Faculté de Pharmacie, Clermont-Ferrand, France.
By addition of methylisocyanate to 5-arylidene 2-aminoalkyl 3-pyridazinones a series of derivatives substituted in the 2-position by an ureidoalkyl moiety was obtained in good yields. Gastric antisecretory and anti-ulcer activities of these new compounds were evaluated. The influence of the substituents attached to the pyridazine ring was discussed.
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