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Leydig cell function in 21 boys with acute lymphoblastic leukemia who had been treated by bilateral direct testicular irradiation (12 X 2 Gy) at 8.4 +/- 0.7 years, was evaluated 3.8 +/- 0.4 years after irradiation. At the time of irradiation all were prepubertal and at evaluation 12 were prepubertal and 9 pubertal. Leydig cell insufficiency, indicated by a low plasma testosterone response to chorionic gonadotrophin and/or an increase in basal level of plasma luteinizing hormone, was observed in 19/21 patients. The children who were the youngest at testicular irradiation were more vulnerable. Spontaneous virilization occurred in 3 of the older children and resulted from compensated Leydig cell dysfunction.
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
July 1983,
The New England journal of medicine,
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
January 1985,
Medical and pediatric oncology,
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
September 1985,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
August 1981,
The New England journal of medicine,
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
October 1981,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
May 2018,
Pediatric blood & cancer,
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
August 1990,
The Journal of pediatrics,
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
November 1983,
Archives of disease in childhood,
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
June 1986,
Archives of disease in childhood,
R Brauner, and
P Caltabiano, and
R Rappaport, and
G Leverger, and
G Schaison
May 1999,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
