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Bioorthogonal Phosphorogenic Rhenium(I) Polypyridine Sydnone Complexes for Specific Lysosome Labeling. 2020

Justin Shum, and Pei-Zhi Zhang, and Lawrence Cho-Cheung Lee, and Kenneth Kam-Wing Lo
Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.

Invited for this month's cover is the group of Prof. Kenneth Kam-Wing Lo at City University of Hong Kong, Hong Kong, P. R. China. The cover picture shows the selective landing of a bioorthogonal spacecraft on a lysosomal planet modified with a strained cyclooctyne moiety in an intracellular environment with other organelles and a plethora of biomolecules. A sydnone moiety is appended to a luminescent rhenium(I) diimine unit as both an emission quencher and a bioorthogonal handle. Selective strain-promoted sydnone-alkyne cycloaddition (SPSAC) of the complex with a strained alkyne leads to impressive emission turn-on, which can be exploited in bioimaging and phototherapeutic applications. Read the full text of the article at 10.1002/cplu.202000029.

UI MeSH Term Description Entries
D008247 Lysosomes A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured or undergoes MEMBRANE FUSION. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed). Autolysosome,Autolysosomes,Lysosome
D011725 Pyridines Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D012211 Rhenium A metal, atomic number 75, atomic weight 186.207, symbol Re.
D017553 Phosphorus Compounds Inorganic compounds that contain phosphorus as an integral part of the molecule. Compounds, Phosphorus

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