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Responses of isolated spinal cord neurons of lamprey on glycine and gamma-aminobutyric acid (GABA) were investigated by means of intracellular perfusion and concentration clamp techniques. Responses on both amino acids exhibited fast but not full desensitization. Preincubation of neurons in the solution of one mediator led to full disappearance of the response to other mediator. It is suggested that these amino acids act on the same channel-receptor complex.
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