Biomaterial Database

[Effect of dental varnish containing fluoride either with CPP-ACP or bioglass on root caries]. 2020

Yang Sun, and Chen-Zhi Gao

Department of Stomatology, Peking University People's Hospital. Beijing 100044, China. E-mail:zhidu8858@163.com.

OBJECTIVE To investigate the effect of dental varnish containing fluoride either with casein phosphopeptide-amorphous calcium phosphate(CPP-ACP) or bioglass on root caries. METHODS The active roots collected in Peking University People's Hospital from April 2017 to October 2018 were randomly divided into group A, group B, group C, and group D, each with 18 teeth. All groups received toothbrushing containing fluoride, in addition, group B received another 5% sodium fluoride, group C added 5% sodium fluoride + CPP-ACP, and group D added 5% sodium fluoride + bioglass. The severity, surface roughness and mineral concentration of root caries before and after brushing were observed. SPSS 23.0 software package was used to determine the correlation between root severity and surface roughness. RESULTS After 50 days of brushing, the hardness of group B, C and D was significantly improved (P<0.05), and was significantly better than that of group A (P<0.05). The hardness was the highest in group D after 50 days of brushing, followed by group C and B, with significant difference(P<0.05). The surface roughness scores of group B and C were significantly higher than those of group A and D after 7 days of brushing(P<0.05). The surface roughness scores of group B were significantly higher than those of group A, C and D after 14 days of brushing(P<0.05). The surface roughness scores of group D were significantly higher than those of group B and C after 50 days of brushing(P<0.05). The severity score of root caries in group A was negatively correlated with surface roughness (P<0.05). The mineral concentration of each group was increased 50 days after brushing (P<0.05). CONCLUSIONS Application of dental varnish containing fluoride either with CPP-ACP or bioglass can effectively prevent root caries. Compared with CPP-ACP, bioglass is more stable, and can effectively improve the mineral concentration on tooth surface.

UI	MeSH Term	Description	Entries
D008903	Minerals	Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Mineral
D010150	Paint	An emulsion of solid color which when spread over a surface leaves a thin decorative and or protective coating.	Varnish,Paints
D002327	Cariostatic Agents	Substances that inhibit or arrest DENTAL CARIES formation. (Boucher's Clinical Dental Terminology, 4th ed)	Cariostatic Effect,Cariostatic Effects,Agent, Cariostatic,Agents, Cariostatic,Cariostatic Agent,Effect, Cariostatic,Effects, Cariostatic
D002364	Caseins	A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.	alpha-Casein,gamma-Casein,AD beta-Casein,Acetylated, Dephosphorylated beta-Casein,Casein,Casein A,K-Casein,Sodium Caseinate,alpha(S1)-Casein,alpha(S1)-Casein A,alpha(S1)-Casein B,alpha(S1)-Casein C,alpha(S2)-Casein,alpha-Caseins,beta-Casein,beta-Caseins,epsilon-Casein,gamma-Caseins,kappa-Casein,kappa-Caseins,AD beta Casein,Caseinate, Sodium,K Casein,alpha Casein,alpha Caseins,beta Casein,beta Caseins,beta-Casein Acetylated, Dephosphorylated,beta-Casein, AD,epsilon Casein,gamma Casein,gamma Caseins,kappa Casein,kappa Caseins
D002516	Ceramics	Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)	Ceramic
D003731	Dental Caries	Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	Caries, Dental,Carious Lesions,Dental Cavities,Dental Cavity,Dental Decay,Dental White Spots,Carious Dentin,Decay, Dental,Dental White Spot,White Spot, Dental,White Spots, Dental,Carious Dentins,Carious Lesion,Cavities, Dental,Cavity, Dental,Dentin, Carious,Dentins, Carious,Lesion, Carious,Lesions, Carious,Spot, Dental White,Spots, Dental White
D005459	Fluorides	Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.	Fluoride
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014089	Tooth Remineralization	Therapeutic technique for replacement of minerals in partially decalcified teeth.	Remineralization, Tooth
D017213	Root Caries	Dental caries involving the tooth root, cementum, or cervical area of the tooth.	Caries, Cervical,Caries, Root,Cervical Caries,Cary, Cervical,Cervical Cary