The effect of selected Lactobacillus strains on dextran sulfate sodium-induced mouse colitis model. 2020

Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
1Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Inflammatory bowel disease (IBD) comprises two major illnesses: Crohn's disease (CD) and ulcerative colitis (UC). Dextran sulfate sodium (DSS) mouse colitis model has been used in understanding the mechanism of IBD. This study was conducted to examine selected Lactobacillus spp. as potential IBD treatment in the DSS-induced animal model. Balb/c mice were used and colitis was induced by adding 5% dextran sodium sulfate into the drinking water for 8 days. Colon length, disease activity index (DAI) and histological analysis were measured as markers of inflammation in DSS colitis mice. The majority of the Lactobacillus species significantly prevented the shortening of the colon length compared with the DSS group. The DAI scores of mice were significantly reduced following usage of four Lactobacillus strains included: Lactobacillus plantarum 03 and 06, Lactobacillus brevis 02 and Lactobacillus rhamnosus 01. The histological analysis exhibited that oral administration of Lactobacillus strains had therapeutic effects on mice colitis. L. plantarum and L. brevis showed better therapeutic effect against DSS-induced acute colitis mice. The probiotic activities of these three isolates indicated that the probiotic effects were strain specific and none of these useful bacteria could exhibit all of the valued probiotic properties simultaneously.

UI MeSH Term Description Entries
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D003092 Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER. Colitides
D003106 Colon The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. Appendix Epiploica,Taenia Coli,Omental Appendices,Omental Appendix,Appendices, Omental,Appendix, Omental
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005260 Female Females
D000069196 Gastrointestinal Microbiome All of the microbial organisms that naturally exist within the GASTROINTESTINAL TRACT. Enteric Bacteria,Gastric Microbiome,Gastrointestinal Flora,Gastrointestinal Microbial Community,Gastrointestinal Microbiota,Gastrointestinal Microflora,Gut Flora,Gut Microbiome,Gut Microbiota,Gut Microflora,Intestinal Flora,Intestinal Microbiome,Intestinal Microbiota,Intestinal Microflora,Bacteria, Enteric,Flora, Gastrointestinal,Flora, Gut,Flora, Intestinal,Gastric Microbiomes,Gastrointestinal Microbial Communities,Gastrointestinal Microbiomes,Gastrointestinal Microbiotas,Gut Microbiomes,Gut Microbiotas,Intestinal Microbiomes,Intestinal Microbiotas,Microbial Community, Gastrointestinal,Microbiome, Gastric,Microbiome, Gastrointestinal,Microbiome, Gut,Microbiome, Intestinal,Microbiota, Gastrointestinal,Microbiota, Gut,Microbiota, Intestinal,Microflora, Gastrointestinal,Microflora, Gut,Microflora, Intestinal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016264 Dextran Sulfate Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications. Sodium Dextran Sulfate,Dextran Sulfate Sodium,Dextran Sulfate, Sodium,Sulfate Sodium, Dextran,Sulfate, Dextran,Sulfate, Sodium Dextran
D048191 Lactobacillus plantarum A species of rod-shaped, LACTIC ACID bacteria used in PROBIOTICS and SILAGE production.
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
August 2017, Bio-protocol,
Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
January 2016, PloS one,
Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
July 2023, Journal of microbiology (Seoul, Korea),
Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
March 1998, The American journal of physiology,
Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
November 2017, Journal of medicinal food,
Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
January 2019, PloS one,
Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
June 2019, Journal of cancer prevention,
Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
August 1998, Digestive diseases and sciences,
Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
January 2019, Biological & pharmaceutical bulletin,
Meysam Hasannejad-Bibalan, and Ali Mojtahedi, and Morteza Eshaghi, and Mahdi Rohani, and Mohammad Reza Pourshafie, and Malihe Talebi
February 2014, Inflammation research : official journal of the European Histamine Research Society ... [et al.],
Copied contents to your clipboard!