Biomaterial Database

The absence of cardiovascular and respiratory responses to changes in right ventricular pressure in anaesthetized dogs. 1988

A J Crisp, and R Hainsworth, and S M Tutt

Department of Cardiovascular Studies, University of Leeds.

1. This study was undertaken to determine whether physiological changes in pressure localized to the right ventricle result in reflex cardiovascular or respiratory responses. 2. Right ventricular systolic pressure was changed using a preparation in which right atrial and carotid sinus pressures were held constant. The pulmonary and hence the systemic circulation were perfused at constant flow. Vascular resistance and respiratory activity were assessed from the systemic arterial pressure and the phrenic electroneurogram. 3. Changes in right ventricular systolic pressure did not result in any consistent changes in heart rate, systemic arterial blood pressure or phrenic nerve activity. 4. Expected responses occurred to changes in the stimuli to carotid baroreceptors and chemoreceptors, distension of pulmonary arterial baroreceptors, and injections of veratridine into the left ventricle and pulmonary circulation. This suggests that the absence of responses to right ventricular distension was unlikely to have been due to damage to nervous pathways. 5. These results indicate that it is unlikely that there are reflexes arising from the right ventricle which have a major role in cardiovascular or respiratory control.

UI	MeSH Term	Description	Entries
D010791	Phrenic Nerve	The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.	Nerve, Phrenic,Nerves, Phrenic,Phrenic Nerves
D011311	Pressoreceptors	Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.	Baroreceptors,Receptors, Stretch, Arterial,Receptors, Stretch, Vascular,Stretch Receptors, Arterial,Stretch Receptors, Vascular,Arterial Stretch Receptor,Arterial Stretch Receptors,Baroreceptor,Pressoreceptor,Receptor, Arterial Stretch,Receptor, Vascular Stretch,Receptors, Arterial Stretch,Receptors, Vascular Stretch,Stretch Receptor, Arterial,Stretch Receptor, Vascular,Vascular Stretch Receptor,Vascular Stretch Receptors
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002628	Chemoreceptor Cells	Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.	Chemoreceptive Cells,Cell, Chemoreceptive,Cell, Chemoreceptor,Cells, Chemoreceptive,Cells, Chemoreceptor,Chemoreceptive Cell,Chemoreceptor Cell
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006321	Heart	The hollow, muscular organ that maintains the circulation of the blood.	Hearts
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000771	Anesthesia, Intravenous	Process of administering an anesthetic through injection directly into the bloodstream.	Anesthesias, Intravenous,Intravenous Anesthesia,Intravenous Anesthesias