Biomaterial Database

Antibody producing ability of mouse spleen cells after subacute dietary exposure to T-2 toxin. 1988

R S Tomar, and B R Blakley, and W E DeCoteau

Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Canada.

The effects of T-2 toxin on the antibody producing ability of CD-1 mice after dietary exposure to 0, 2.5, 5 and 15 ppm of T-2 toxin for 29 days was studied. The antibody response against sheep red blood cells, a T-lymphocyte and macrophage-dependent response was suppressed at 2.5, 5 and 15 ppm of T-2 toxin exposure. In contrast, the antibody responses against dinitrophenyl-aminoethylcarbamylmethyl - Ficoll (DNP - Ficoll), a T-lymphocyte independent macrophage-dependent response, and Escherichia coli 0127 (LPS), a T-lymphocyte and macrophage-independent response, were not affected. These results suggest that the inhibitory effects of T-2 toxin on antibody-producing ability after subacute dietary exposure appear to be a direct affect on T-lymphocyte function, possibly involving the T-helper lymphocytes.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D004140	Dinitrophenols	Organic compounds that contain two nitro groups attached to a phenol.
D004306	Dose-Response Relationship, Immunologic	A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.	Immunologic Dose-Response Relationship,Relationship, Immunologic Dose-Response,Dose Response Relationship, Immunologic,Dose-Response Relationships, Immunologic,Immunologic Dose Response Relationship,Immunologic Dose-Response Relationships,Relationship, Immunologic Dose Response,Relationships, Immunologic Dose-Response
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000917	Antibody Formation	The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.	Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D000955	Antigens, T-Independent	Antigens which may directly stimulate B lymphocytes without the cooperation of T lymphocytes.	T-Independent Antigens,Thymus-Independent Antigens,Antigens, T Independent,TI-2 Antigens,Antigens, TI-2,Antigens, Thymus-Independent,Independent Antigens, T,T Independent Antigens,TI 2 Antigens,Thymus Independent Antigens