Endoscopic laser therapy may be useful in controlling upper gastrointestinal bleeding due to vascular abnormalities. This report presents the case of an 11-year-old boy with an unusual vasculocutaneous disorder complicated by chronic recurrent bleeding that necessitated frequent blood transfusions. Of a number of investigative tests, only endoscopy was diagnostic in determining that the bleeding was secondary to multiple gastric vascular lesions. Moreover, laser photocoagulation of the identified lesions resulted in a dramatic decrease in both transfusion requirements and hospitalization.