Biomaterial Database

[Rational HLA-A, -B, -C typing in rheumatology]. 1988

G Haberhauer, and H Bröll

Medizinischen Abteilung mit Rheumatologie, Osteologie und rheumaserologischem Labor, Kaiser-Franz-Josef-Spital der Stadt Wien.

In the own laboratory of our department from 1984-1987 367 patients with several rheumatic diseases were tissue-typed for HLA-A, B, C-antigens. Associations with diseases and clinical parameters were examined. We could only find significant associations (P corr. less than 0.05) of HLA-B 27 with reactive arthritis and iliosacral arthritis. We conclude, that the B 27-test is sufficient for economic HLA-typing in rheumatology.

UI	MeSH Term	Description	Entries
D005787	Gene Frequency	The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.	Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D006680	HLA Antigens	Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.	Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012216	Rheumatic Diseases	Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.	Rheumatism,Disease, Rheumatic,Diseases, Rheumatic,Rheumatic Disease
D012217	Rheumatoid Factor	Autoantibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.	Factor, Rheumatoid
D015234	HLA-A Antigens	Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.	Antigens, HLA-A,HLA-A,Antigens, HLA A,HLA A Antigens
D015235	HLA-B Antigens	Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.	Antigens, HLA-B,HLA-B Antigen,HLA-B,Antigen, HLA-B,Antigens, HLA B,HLA B Antigen,HLA B Antigens
D015236	HLA-C Antigens	Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).	Antigens, HLA-C,HLA-C,Antigens, HLA C,HLA C Antigens