Biomaterial Database

Some effects of sleep loss on vestibular responses. 1988

W E Collins

Human Resources Research Branch, FAA Civil Aeromedical Institute, Oklahoma City, Oklahoma 73125.

This study assessed ocular nystagmus and motion experiences of men exposed to both simple (angular acceleration) and complex (Coriolis) vestibular stimulation during approximately 55 h of sleep loss. Control and sleep-deprived groups each comprised 10 young men. Angular accelerations and Coriolis stimulation (30 degrees head movements during CW rotation) were accomplished in darkness in an enclosed Still-Werner rotating device. Nystagmus and motion experiences (turning, "diving," and "climbing") were recorded throughout each session. Tests were given at 0900 and 1300 on each of 3 successive days. Subjects ingested 10-mg of d-amphetamine at 1200 on Day 3. During simple stimulation, the sleep-deprived group showed regular declines across sessions in slow phase and duration measures of nystagmus but fast phase ocular frequency and measures of experienced turning resisted declines until the final predrug session; subjective response latencies increased with sleep loss. Declines during rotation for ocular output and measures of perceived displacement during rightward head tilts ("climbing" sensation) were obtained for the sleep deprived, but both nystagmus and sensations were unaffected by return (leftward) movements of the head ("diving" sensation). d-Amphetamine had no consistent effect on responses of control subjects, but significantly increased nystagmus and elevated (but not significantly) measures of turning experiences for the sleep deprived.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009760	Nystagmus, Physiologic	Involuntary rhythmical movements of the eyes in the normal person. These can be naturally occurring as in end-position (end-point, end-stage, or deviational) nystagmus or induced by the optokinetic drum (NYSTAGMUS, OPTOKINETIC), caloric test, or a rotating chair.	Nystagmus, Barany,Nystagmus, Caloric,Nystagmus, End-Position,Nystagmus, Positional,Nystagmus, Post-Rotatory,Nystagmus, Thermal,Nystagmus, Barany's,Nystagmus, Physiological,Physiologic Nystagmus,Barany Nystagmus,Barany's Nystagmus,Caloric Nystagmus,End-Position Nystagmus,Nystagmus, Baranys,Nystagmus, End Position,Nystagmus, Post Rotatory,Physiological Nystagmus,Positional Nystagmus,Post-Rotatory Nystagmus,Thermal Nystagmus
D011930	Reaction Time	The time from the onset of a stimulus until a response is observed.	Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D003312	Coriolis Force	The apparent deflection (Coriolis acceleration) of a body in motion with respect to the earth, as seen by an observer on the earth, attributed to a fictitious force (Coriolis force) but actually caused by the rotation of the earth. In a medical context it refers to the physiological effects (nausea, vertigo, dizziness, etc.) felt by a person moving radially in a rotating system, as a rotating space station. (From Random House Unabridged Dictionary, 2d ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Coriolis Acceleration,Coriolis Effect,Coriolis Stimulation,Acceleration, Coriolis,Effect, Coriolis,Force, Coriolis,Stimulation, Coriolis
D003913	Dextroamphetamine	The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.	d-Amphetamine,Curban,Dexamfetamine,Dexamphetamine,Dexedrine,Dextro-Amphetamine Sulfate,DextroStat,Dextroamphetamine Sulfate,Oxydess,d-Amphetamine Sulfate,dextro-Amphetamine,Dextro Amphetamine Sulfate,Sulfate, Dextroamphetamine,d Amphetamine,d Amphetamine Sulfate,dextro Amphetamine
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012399	Rotation	Motion of an object in which either one or more points on a line are fixed. It is also the motion of a particle about a fixed point. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Clinorotation,Clinorotations,Rotations
D012892	Sleep Deprivation	The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.	Inadequate Sleep,Insufficient Sleep,Insufficient Sleep Syndrome,REM Sleep Deprivation,Sleep Debt,Sleep Fragmentation,Sleep Insufficiency,Deprivation, REM Sleep,Deprivation, Sleep,Fragmentation, Sleep,Insufficiencies, Sleep,Insufficiency, Sleep,Insufficient Sleep Syndromes,Sleep Deprivation, REM,Sleep Insufficiencies,Sleep, Inadequate,Sleep, Insufficient,Syndrome, Insufficient Sleep
D014722	Vestibule, Labyrinth	An oval, bony chamber of the inner ear, part of the bony labyrinth. It is continuous with bony COCHLEA anteriorly, and SEMICIRCULAR CANALS posteriorly. The vestibule contains two communicating sacs (utricle and saccule) of the balancing apparatus. The oval window on its lateral wall is occupied by the base of the STAPES of the MIDDLE EAR.	Vestibular Apparatus,Ear Vestibule,Vestibular Labyrinth,Vestibule of Ear,Vestibulum Auris,Apparatus, Vestibular,Ear Vestibules,Labyrinth Vestibule,Labyrinth Vestibules,Labyrinth, Vestibular,Labyrinths, Vestibular,Vestibular Labyrinths,Vestibule, Ear,Vestibules, Ear,Vestibules, Labyrinth