Biomaterial Database

Human urinary epidermal growth factor excretion: age, sex, and race dependence. 1988

D M Stoll, and L E King, and L McNeil, and D N Orth

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232.

We measured the urinary excretion of immunoreactive epidermal growth factor (IR-EGF) in random urine specimens obtained from 358 ambulatory patients and normal subjects, aged 18-90 yr, with a homologous EGF RIA. We also measured IR-EGF excretion in 24-h urine collections from 40 additional normal subjects, aged either 20-29 or 60-69 yr, to detect possible artifacts introduced in the analysis of random urine specimens by the age-related decline in the glomerular filtration rate. Urinary IR-EGF excretion decreased in a linear fashion with increasing age. Women excreted more IR-EGF than men, and whites excreted more IR-EGF than blacks of the same age and sex, but the rate of decline with increasing age was similar for all groups. These findings may provide additional insight into the role of EGF in human renal physiology.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D004815	Epidermal Growth Factor	A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.	EGF,Epidermal Growth Factor-Urogastrone,Urogastrone,Human Urinary Gastric Inhibitor,beta-Urogastrone,Growth Factor, Epidermal,Growth Factor-Urogastrone, Epidermal,beta Urogastrone
D005260	Female		Females
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000369	Aged, 80 and over	Persons 80 years of age and older.	Oldest Old